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Upon hypoxia, HIF-1 is stabilized and translocates to the nucleus, where it dimerizes with HIF-1, binds to target genes, and activates gene transcription

phagocytophilum does not suppress a global respiratory burst, and may instead selectively exclude cytb 558 from the phagosomal membrane (IJdo and Mueller, 2004)

Another effect of AT1 receptor overstimulation is the activation of NOX5, NF-B, IL-6 and STAT3, which exacerbates oxidative stress and causes overproduction of pro-inflammatory cytokines (including IL-6, IL-1 and TNF-) (268, 275277)

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Antioxidants Vol

doi: 10.1016/j.freeradbiomed.2005.07.010